![]() ![]() What are the strongest Nespresso pods?īlack Insomnia Smooth Roast Coffee Pods, The Strongest Coffee in The World, Nespresso Original Compatible Coffee Pods, 100% Home Compostable x 20. Doppio is Italian multiplier, meaning “double”. This results in 60 ml (2.1 imp fl oz 2.0 US fl oz) of drink, double the amount of a single shot espresso. How big is a doppio?ĭoppio espresso (Italian pronunciation: ) is a double shot which is extracted using double the amount of ground coffee in a larger-sized portafilter basket. Vertuo Next is a new generation of Nespresso coffee machines, which can brew everything from a full carafe of coffee to a large mug or a small Espresso. Can I make a large coffee with Nespresso? The lungo blends contain 20% more coffee per capsule therefore, they have slightly higher caffeine content, about 77-89 mg. ![]() The caffeine content per brewed espresso capsule will vary between approximately 55 and 65 mg. If you have ever let your water reservoir run dry (and who hasn’t), then you might have sucked some air into your Nespresso machine This will affect the pressure inside and might mean you are not getting the full Nespresso experience. Why is my Nespresso machine not making a full cup? The second cup tasted fine the only difference is it was a bit weaker than the first cup, but it still tasted great. Normally, we grind at 9 or so on the Breville Barista Pro for a normal espresso, using 18g of coffee in to pull our shotĪll you do is use each pod twice ! After using the Nespresso pod to make your cappuccino or espresso, simply put the pod back into the machine and have it make you another cup. For ristretto and lungo, add 10 and 20 ml of milk accordingly. Can you put milk in a lungo?įirst, brew the espresso coffee (40ml or 1.35 fl oz) with your coffee machine and pour it into the cup. If the cup is too big, the crema spreads out, becomes thin, and disappears quickly. What size is an espresso?Įspresso cup size Consider that an espresso is about 60 ml The cup in which this coffee is served should be no bigger than 90ml. The saucers are dishwasher safe but are not suitable for microwave and oven use. The VIEW Collection saucers are made of stainless steel 18/10, a very durable material, but sensitive to scratching. Are Nespresso lungo cups microwave safe?īoth cups and saucers are dishwasher safe. While espressos are extracted for 25 to 35 seconds, Lungos keep going.and going.and going they stop anywhere from 45 seconds to a minute. It’s called an “Americano” when the water comes after the espresso Lungo stands for “Long” in Italian – it’s a long espresso. It is a long-cup that stimulates the senses through its high intensity and generous character This dark roasted coffee is a blend of a distinctive Arabica from India with a Robusta from Mexico. Envivo Lungo was specially designed for the morning by Nespresso Coffee Experts. Can I make a lungo using a Nespresso espresso capsule?Ĭan I Make a Lungo Using a Nespresso Espresso Capsule? This is actually quite important – you should not make an espresso using a lungo capsule or vice versa! The coffee blends and their respective flavours are put together specifically with the extraction time in mind. The drink should be between 1 ½ – 2 ounces. Put portafilter into the grouphead and pull lungo shots There should be more water in a lungo shot so pull a longer shot than you would an espresso. It’s prepared with the same amount of finely ground coffee and twice the water of a normal espresso shot. The word “lungo” literally means “long”, and the “lungo” gets its name from the way it’s made It is made with a so-called “long pull” (slower and more voluminous extraction) of espresso. Latte macchiato 40 ml coffee / 150ml milk. How many ml is a Nespresso lungo?ġ10 ml Lungo, 40 ml Espresso, 25 ml Ristretto. What is a lungo size?Īssuming a 30g dose of ground coffee, a ristretto solo is thus 30 ml (1 fl oz) (the foamy crema slightly increases this volume), normale is 60 ml (2 fl oz), and lungo is 90–120 ml (3–4 fl oz). Lungos are made with about twice as much water, so they’re larger than espresso shots A regular shot has about one ounce of espresso and a lungo shot makes two ounces. Lungos are double the size of espresso shots, at 3 to 4 ounces, and take about 30 seconds to brew. How Much Espresso Is In A Lungo? An espresso typically weighs one cup, but a typical espresso is one cup. To discover how you can enjoy five different cup sizes, click here. ![]() If you enjoy a range of extraction sizes and coffee styles, the Vertuo system could be your ideal solution. The lungo capsules contain coffee of a coarser grind. A Lungo is a 110 mL shot of coffee (the large cup button). ![]()
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![]() ![]() Protein powder gives them their “oomph,” while rolled oats, bananas and maple syrup make them worthy of seconds.ħ. We’d like to put that myth to rest by offering up these ever-so-healthy AND delicious protein waffles. With famous waffle places like The Waffle House, these morning staples sometimes get a bad rap as unhealthy greasy spoon kind of fare. Vegan Protein Powder Waffles Photo: One Clever Chef Applesauce and honey give it that pie-like quality, while a dose of protein powder keeps your blood sugar steady all morning.Ħ. That’s for sure, especially considering what a treat like this apple pie baked oatmeal brings to your breakfast table. Who says apple pie belongs only on the dessert menu? We don’t. Apple Pie Baked Oatmeal Photo: Secretly Healthy Home If you’re really daring, try substituting chocolate powder for a naughty taste kick.ĥ. In this case, vanilla protein powder adds a sugar-calming yet tasty effect to the recipe. If your blood sugar gets all spikey and temperamental when you eat bananas, a hefty dose of high-quality protein calms the sugar high down. Banana Protein Powder Muffins Photo: Okonomi Kitchen Oatmeal beefs up the texture and flavor, while the blueberries offer a burst-in-your-mouth WOW factor that’s worth sinking your teeth into!Ĥ. For them, these blueberry numbers work just fine. Some people find the texture of protein powders to be a bit off-putting. Let’s grab the elephant in the room by the tusks. Blueberry Protein Oatmeal Cups Photo: Kay’s Clean Eats A drizzle of syrup makes it right as rain.ģ. This powder has all the nutritional punch of peas without the green that kids – and even some adults – hate. Just whip up his favorite flapjack recipe and toss in some pea powder when no one’s looking. Here’s one sneaky way extra protein can infiltrate your kid’s pancakes. Vegan Protein Powder Pancakes Photo: The Conscious Plant Kitchen A dash of vanilla or chocolate protein powder to finish it off gives it stick-to-your-ribs staying power. Your overnight oats become morning comfort food when you combine every kid’s favorite gooey mouthful of deliciousness, peanut butter, with a dollop of maple syrup. Vegan Protein Overnight Oats Photo: The Almond Eater To find more tasty vegan high protein recipes, see our high protein vegan meals, silken tofu, weight loss, TVP, soy curl, smoked tofu and high protein vegan breakfasts roundups. However, more experienced foodies know that this magic substance adds a low-calorie source of flavor and protein to otherwise plain recipes, like overnight oats or pancakes, energy bites or cookies. You need only add some plant milk and berries in the blender to whip up a protein shake. ![]() 30+ Tasty Protein Powder Recipes (Not Shakes!)įor inexperienced protein powder users, seemingly inert dust equals a thick, questionably delicious meal replacement.Up the nutrition and flavor of your protein shake by adding in one (or more) of these ingredients.įor more protein shake inspiration, visit the Vega Recipe Center. ![]() Now that you have some great ideas for some plant-based protein smoothie ingredient ideas, it’s time to look at some good fat options to add to your smoothie. Protein shakes with purpose!Ĭlick on the highlighted ingredients for inspirational recipe ideas to help destroy your smoothie rut.Įver wondered which plant-based foods are sources of protein and taste great in a smoothie? Here are a few options to get you started. It’s now time to step out of that rut and make yourself the best protein shakes of your life. You stick to it, because it has everything you want: protein, fats and maybe some extra goodies like greens. Sure, you like the taste, but you’re starting to really despise these ingredients and even the smell of them is making you feel unmotivated about your once fabulous smoothie. ![]() We make our post-workout smoothie and realize that we’ve been drinking this same concoction for the last two weeks straight. We’ve all gotten stuck in a smoothie rut before, whether we’re creatures of habit or just don’t really feel like being creative. ![]() ![]() ![]() You cannot collect paper Canadian Tire Money on bonus offers. † In the form of electronic Canadian Tire Money® (CT Money®). Examples of borrowing costs (rounded to the nearest cent) assuming that all charges are purchases bearing interest at the regular annual rate of 20.99%, a 30 day month, no charges made on special payment plans and no other fees, additional payments or other changes are: The Triangle Mastercard and the Triangle World Elite Mastercard do not have an annual fee. The billing period covered by each statement can be from 28-33 days. For residents of Quebec, the period between the statement date and the due date for payment is 26 days. ![]() The minimum payment is the sum of (a) the greater of: (i) interest and fees shown on your statement + $10 or (ii) 5% of the New Balance, excluding amounts on special payment plans, (b) any balance over your credit limit, (c) any amounts past due not included in (b) above, and (d) the amount of any equal payments plan instalments then due. Some applicants may receive a higher or lower regular annual rate depending on a credit evaluation. Offer subject to change without notice.Īdditional information for residents of Quebec only: The regular annual rate for persons applying for the Triangle Mastercard and the Triangle World Elite Mastercard is 22.99% for cash transactions and related fees and 20.99% for all other charges. Any unpaid portion not received by the due date will no longer form part of the equal payments plan and interest will accrue on that amount from the day after the date of your next statement at the applicable regular annual rate. Each month during an equal payments plan you are required to pay in full by the due date that month’s equal payments plan instalment. There is no administration fee charged for entering into a special payments plan. However, if we do not receive the full minimum due on a statement within 59 days of the date of that statement, or any event of default (other than a payment default) occurs under your Cardmember Agreement, all special payment plans on your account will terminate and (i) you will then be charged interest on the balances outstanding on such plans at the applicable regular annual rate from the day after the date of your next statement, and (ii) the balances outstanding will form part of the balance due on that statement. Interest does not accrue during the period of the plan. Dealers may sell for less.įinancing available is “Equal payments, no interest” for 24 months (unless otherwise stated) and is only available on request, on approved credit and on purchases of $150 (unless otherwise stated) or more (Gift Cards excluded) made with your Triangle credit card at Canadian Tire, Sport Chek, Mark’s, L’Équipeur, Atmosphere, Sports Rousseau, Hockey Experts, L’Entrepôt du Hockey and participating Sports Experts. **Online prices and sale effective dates may differ from those in-store and may vary by region. ±Was price reflects the last national regular price this product was sold for. The tire producer / manufacturer and Canadian Tire uses this fee to pay for the collection, transportation, and processing of used tires.ĬANADIAN TIRE® and the CANADIAN TIRE Triangle Design are registered trade-marks of Canadian Tire Corporation, Limited. The 38” broom stores neatly inside the dust pan and both are equipped with convenient hanger holes for easy storage.△The tire producer / manufacturer of the tires you are buying, and Canadian Tire is responsible for the recycling fee that is included in your invoice. The 10” wide sweeping width and 3.75” fibers made from recycled PET gives the user excellent floor coverage and can be used on any surface. The large-capacity dust pan features teeth to remove debris from the broom fibers and a simple handle clip for easy storage when not in use. Make mobile cleaning easy with the Libman Lobby Dust Pan & Broom set. ![]() ![]() Shape Router is able to route complex layouts with SMD components as well as single-layer boards. Grid Router can also make single-layer boards with jumper wires. With Specctra DSN/SES interface you can use external shape-based or topological autorouter. Intelligent manual routing tools allow you to create and edit traces by 90, 45 degree or without any limitations. Through, blind or buried vias can be used in automatic and manual routing. ![]() Powerful copper pour system can help to reduce your manufacturing costs by minimizing the amount of etching solution required. To use it, all you have to do is insert a copper area on your board in the PCB Layout program and any pad or trace inside the selected area will be automatically surrounded with a gap of the desired size. Using copper pour you can also create planes and connect them to pads and vias (different thermal types are supported). Schematic and PCB design modules have number of verification features that help control project accuracy on different design stages: The ERC function shows possible errors in Schematic pin connections using defined rules and allows you to correct errors step-by-step. DRC function checks the clearance between design objects, minimum size of traces, and drills. Errors are displayed graphically and you can fix them step-by-step and rerun the DRC in one click after any corrections. Net Connectivity Check verifies if all nets of PCB are electrically connected. This feature uses traces, copper pour filled area and shapes to control connectivity, then reports broken and merged nets with area details. Comparing to Schematic allows you to check if routed PCB is identical with Schematic. Using DipTrace Schematic or Component Editor specify spice settings or attach models to the components. cir net-list of your Schematic to LT Spice or another simulation software to verify how it works. ![]() Package modules allow you to exchange schematics, layouts and libraries with other EDA and CAD packages (DXF, Eagle, P-CAD, PADS, OrCAD). DipTrace Schematic Capture and PCB Layout also support Accel, Allegro, Mentor, PADS, P-CAD, Protel and Tango netlist formats.ĭipTrace provides support for a number of different manufacturing output formats. ![]() Using this PCB software you can produce N/C Drill files for numerically controlled (N.C.) drilling machines and RS-274X Gerber files for sending to board manufacturers. Vectorizing function allows to export true-type fonts and raster images. Also DipTrace supports DXF output.ĭipTrace allows you to export edge polylines to DXF. The DXF files can be converted to G-code with Ace Converter (it’s free). Before edge exporting the DRC function of pcb layout program checks the design and shows possible problems if exist.ĭipTrace package includes component and pattern libraries which contain 100,000+ components from different manufacturers.Ĭomponent and Pattern Editors allow to design your own symbols and patterns. ![]() ![]() ![]() To confim it's resolved, try starting up Ulead GIF Animator 5 to see if the error can be triggered. Most of your C3D3Trial_E.exe problems should be resolved if the file is placed in the correct file path directory, but it's a good idea to verify it is fixed. Worst-case, you can always attempt to contact Ulead Systems if you cannot find the required file version below. Rare or very old versions of C3D3Trial_E.exe may not be in our current file directory, but you can request a version by clicking "Request" next to your target file version. Recommendation: Scan your PC for C3D3TrialE. Ulead GIF Animator 5 (C3D3TrialE.exe) corrupted during download or install. It comes with a suite of tools that can be used for making the perfect GIF for your technological needs. Another software in conflict with Ulead GIF Animator 5, C3D3TrialE.exe, or shared references. These GIFs can be implemented almost anywhere you need it to, from a Powerpoint to your developing website. You can download a fresh copy of your C3D3Trial_E.exe for %%os%% (and several Windows operating systems) in the table listed below. Ulead Gif Animator is a software program that was developed to allow ease of access to creating GIF files in one application. Dymy do 100 dokadnoci i publikujemy wycznie informacje o formatach plików, które zostay przez nas przetestowane i zweryfikowane. After the problem file is replaced, running a registry scan can help clean up any invalid C3D3Trial_E.exe, file extension, or other file path references which could have been affected from a previous malware infection.ĮXE is utilized by the Windows Executable File format, which are types of Executable Files. Typ pliku Ulead GIF Animator File, opisy oprogramowania dla systemów Mac, Windows, Linux, Android i iOS wymienione na tej stronie byy indywidualnie badane i weryfikowane zespoem PlikiWiki. With this tool, you can create fast-loading. Replacing your EXE file is generally a solution to fixing these issues. Ulead GIF Animator 5.0 is a powerful and easy-to-use software for creating and editing animated. In most cases, C3D3Trial_E.exe file problems are due to the file missing or being corrupted (malware / virus) and often seen at Ulead GIF Animator 5 program startup. ![]() ![]() When it comes to the most popular restaurants to try in town, this beautiful Greek eatery is sure to give you a wonderful experience of fine dining in Tysons Corner. Pricey: As a fine dining establishment with a focus on Greek cuisine and a high level of service, Nostos offers a premium dining experience that comes with a higher price point.Potential for Crowded Dining Space: This might result in a slightly noisy and bustling dining space, which could impact the overall dining experience for those seeking a more intimate or quiet setting.Warm and Inviting Ambiance: The restaurant exudes a cozy Mediterranean charm with its tastefully decorated interior, soft lighting, and rustic accents.Authentic Greek Culinary Journey: From traditional Greek dishes like moussaka and souvlaki to lesser-known delicacies, Nostos offers a unique dining experience that transports diners to the shores of Greece.Nostos is a fine-dining Mediterranean restaurant offering modernized Greek fare and a wide variety of Greek wines. Loved the scalloped potatoes! The wait staff was amazing, making my birthday extra special, once they are aware of the occasion.Eddie V’s Prime Seafood is a sophisticated restaurant offering the finest fresh seafood, prime steaks, and hand-crafted cocktails.Įre are the top 15 Tysons Corner restaurants open right now. The spinach however, had way too much raw garlic, and not enjoyable! I was not crazy about the arugula salad, would have like it better with a mixture of greens. The appetizer of fresh oysters, and both entrees of branzino fish and salmon were cooked to perfection. Upon entering we had great seating, close enough to hear the live band, but far enough away to have conversation. The restaurant is located in an upscale mall, where parking is plentiful, convenient from the interstate or metro train. First thing, a reservation is preferred, as it is popular! The bar scene and the dining room is usually full every afternoon after work hours, into the. This upscale restaurant is the perfect ambiance for spending a birthday, as I did, or any special occasion. It was a lovely evening, made special for us and the attention to the details of our anniversary. We had the bananas foster for dessert and honestly the cake was so good I wished we hadn't added the flambe of alcohol. The food was really good, the steaks were cooked perfectly and the seafood options were robust. To the credit of the dining room where we were seated for dinner there was less of that dress disparity, but still the dress code was ify even though it was posted/communicated, the tables have white linen, and the waiters are in tuxs, so come on, can't we have one adult place where people dress accordingly. While we were dressed up, we sat next to a woman in scrubs, two girls in tank tops, were looking at a table of guys with hoodies and there were people there is raggy jeans, sneakers, and backpacks like it was high school. The bartenders are spot on and pretty efficient with the crowds. We started with drinks in the bar with some light apps - oysters and the filet sliders - both awesome. The hostess staff is young and I don't think they have the gumption to really discern out people based on their attire. establishment takes as a critique to even improve more. So here is the skinny - most good and some other things I hope the. The food is excellent, the service was impeccable, and the venue is topped off by a great view. We selected Eddie V's for our anniversary and it did not disappoint. Restaurants with Outdoor Seating in Tysons Corner.Restaurants for Group Dining in Tysons Corner.Late Night Restaurants in Tysons Corner.Kid Friendly Restaurants in Tysons Corner.Best California Style Pizzas in Tysons Corner.Vegetarian Restaurants in Tysons Corner.Middle Eastern Restaurants in Tysons Corner.Mediterranean Restaurants in Tysons Corner. ![]() Gluten Free Restaurants in Tysons Corner.Asian Restaurants for Families in Tysons Corner.American Restaurants for Special Occasions in Tysons Corner.Restaurants near Eddie V's Prime Seafood.Venice Mall Area McKinley Hill Taguig BGC.Hotels near (DCA) Ronald Reagan National Airport.Hotels near Fairfax County Visitor Information Center.Tysons Corner Hotels with Valet Parking.Tysons Corner Hotels with Walk-in Shower.Tysons Corner Hotels with Tennis Courts. ![]() ![]() ![]() I humbly need help to resolve this problem please. I wish to point out that the PC and Mac are all on the same network. Nicecast reads tracks information from the file location /Library/Application Support/Nicecast/NowPlaying.txt. The problem I have is that I can't send 'Now Playing or Title info' from the RadioDJ to Nicecast. The sound from the Windows PC is sent to a mixer and relayed to Nicecast encoder installed on Mac Pro for broadcast or webcast. I use RadioDJ on a Windows 7 Ultimate platform to play music and commercials. Having said that, my problem has been tackled in various ways on this forum, however, I think mine is different so please pardon me if there happens to be any duplication. By default, Nicecast will select iTunes as the audio source. who continue to push boundries to make RDJ the No.1 radio automation software. How long will it take to set up my SHOUTcast server As soon as you have paid, your order will be processed and your server will be set up instantly. I also would like to commend Marius and fellows like Gary, Andy, Jhonny, etc. Set it for random and repeat, and you’ll have a 24-hour music-only Internet radio station. Otherwise, you'll now be broadcasting to an external server.I am fairly new to RadioDJ and I can't overstate the joy it's brought to my radio station. You can either play individual songs manually or create a playlist. Click Start Broadcast, and Nicecast will attempt to connect to the server. Once you have these settings set up properly, be sure to select the server in the drawer, using the radio button. This should generally be left at Automatic. Being a home user, my upload bandwidth is relatively narrow, and I face severe instability, lag, buffering, and disconnection. I am using Nicecasts built-in server to stream an m3u file to peers at 128k each. This will enable you to set a specific address through which listeners may tune in. Im currently running a fairly small online radio operation from my iMac with Nicecast. Finally, the Public URL may be adjusted manually if you desire. The Mount Point setting is only for icecast servers, so leave this alone if you're not using an icecast server. The Address and Port should also be known. Now you need to enter the actual information about the server. This password shouls already be known to you. However, a password for the server will be needed. The Account is only needed for some server types - if it's grayed out, you may ignore it. Fill in the Server Type popup, which adjusts various under-the-hood settings and provides the proper URLs to the Stream Tracker and the Share drawer. This information is all relative to your remote server, except for the name, which can be anything you like. Now you need to fill in the fields with the appropriate information. This setup will be used to access a remote server. ![]() ![]() Click the External folder, then press New to create a new Server setup. Open the Servers window (press Command-2 or use the Window Menu) and open the drawer by clicking the drawer buttons on top of the window. Once the Broadcast portion of Nicecast is set up, as in our Basic Setup tutorial, you simply need to adjust the settings in the window seen above. You're on the air, using your external server! Click Start Broadcast in the Broadcast window. Finally, switch the radio button in the drawer.Ĥ. Highlight the server, and adjust the settings as needed. Open the Server window, click External in the drawer, and create a New server.ģ. Set up Nicecast as in the Basic Setup tutorial.Ģ. However, for more advanced users, Nicecast also offers the ability to broadcast to an external server, such as a remote copy of Nicecast, a remote icecast/shoutcast server, or a relay server from a company such as Zoe Networks.ġ. these can be found below īeginners will likely wish to use Nicecast's easy built-in server. In order to setup Nicecast please follow the instructions for Nicecast. You should try and drop the stream quality in Nicecast. We always recommend nicecast for mac users which the software and support for this product can be found here…. (I use a pre-Retina Macbook Pro) USB or that line in I am currently using Nicecast but run into big time latency issues when I hijack the audio stream. ![]() ![]() ![]() Updated versions of all 3 of these vaccines are available as of October 2023. This teaches your immune system to attack the COVID-19 virus if it is exposed to it in the future. Once injected into the body, the pieces of protein are recognized by the immune system as foreign. It contains pieces of the COVID-19 virus’s spike protein. The Novavax vaccine is a protein subunit vaccine, which works much like traditional vaccines that have been used for decades. This doesn’t cause disease, but it does help teach the immune system to recognize and attack the virus if the body is exposed to it in the future. After a person gets the vaccine, the mRNA enters cells in the body and tells them to make copies of the COVID-19 virus’s “spike” protein (the protein that normally helps the virus infect human cells). The Pfizer-BioNTech and Moderna vaccines contain messenger RNA (mRNA), which is a type of genetic material. To learn more, see “Recommendations for getting the COVID-19 vaccines” below. The US Centers for Disease Control and Prevention (CDC) has different recommendations for the COVID-19 vaccines, based on the type of vaccine, a person’s age, and whether or not they have a weakened immune system. But no vaccine is 100% effective, so some people who are fully vaccinated might still become infected with COVID-19 and get sick. Īll of these vaccines can lower the risk of being infected with COVID-19, as well as lower the risk of getting very sick, being hospitalized, or dying from COVID-19 if you are infected. ![]() To learn more about these vaccines, visit the FDA’s website at. *A fourth vaccine, made by Johnson & Johnson (Janssen), is no longer available in the US. The Novavax vaccine is authorized for people 12 years of age and older.The Moderna vaccine is authorized for people 6 months to 11 years of age, and is approved (under the brand name Spikevax) for people aged 12 or older.The Pfizer-BioNTech vaccine is authorized for people 6 months to 11 years of age, and is approved (under the brand name Comirnaty) for people aged 12 or older.Three COVID-19 vaccines are available in the US.* These vaccines have been approved or have received emergency use authorization (EUA) from the FDA for the ages below: To learn more, see Vaccinations and Flu Shots for People with Cancer. ![]() Because of this, it’s best to talk with your doctor before getting any type of vaccine. There are some other types of vaccines that might not be safe for some people with cancer, but this depends on many factors, such as the type of vaccine, the type of cancer a person has (had), if they're still being treated for cancer, and if their immune system is working properly. (See “Should cancer patients and survivors get the vaccine?”) However, the vaccine might be less effective in some people with cancer. People with cancer (or with a history of cancer) can get the COVID-19 vaccine safely. Is it safe for people with cancer to get the COVID-19 vaccine? Here we’ll discuss some of the questions people with cancer (or with a history of cancer) or the people caring for them might have about the COVID-19 vaccines. Vaccines (also called immunizations or vaccinations) are available to help protect against COVID-19. (To learn more about COVID-19 and how it might affect people with cancer and their caregivers, see Questions About COVID-19 and Cancer.) COVID-19, caused by the SARS-CoV-2 virus, continues to have an impact on many people, including people with cancer, their families, and caregivers. ![]() ![]() ![]() Tanguay said she was surprised that all five small-molecule mixtures were generally photostable but not surprised that adding zinc oxide particles led to toxicity upon UV irradiation. That suggests zinc oxide particles are leading to degradants whose introduction to aquatic ecosystems is environmentally hazardous.” “Also, the zinc-oxide-induced photodegradation products caused significant increases in defects to the zebrafish we used to test toxicity. “With either size of particle, zinc oxide degraded the organic mixture and caused a greater than 80% loss in organic filter protection against ultraviolet-A rays, which make up 95% of the UV radiation that reaches the Earth,” Santillan said. “Our findings suggest that commercially available small-molecule-based formulas, which were the basis for the formulas we studied, can be combined in different ingredient ratios that minimize photodegradation.”īut scientists saw big differences in photostability and phototoxicity when zinc oxide particles were added – either nanoparticles or the larger microparticles. “There have been several studies that showed sunscreens can quickly react under UV exposure – the specifically intended setting for their use – so it’s pretty surprising how little toxicity testing has been done on the photodegradation products,” Truong said. The scientists also looked at whether the UV radiation had caused any of the mixtures to become toxic to zebrafish, a widely used model organism that goes from egg to swimming in five days, and found that the UV-exposed mixture without zinc oxide did not cause any significant changes in the fish. The researchers then exposed the mixtures to ultraviolet radiation for two hours and used spectroscopy to check their photostability – i.e., what did sunlight do to the compounds in the mixtures and their UV-protective capabilities? They also made additional mixtures with the same ingredients, plus zinc oxide at the lower end of the commercially recommended amount. Scientists including the University of Oregon’s James Hutchinson and Aurora Ginzburg and the University of Leeds’ Richard Blackburn made five mixtures containing the UV filters – the active ingredients in sunscreens – from different products available in the United States and Europe. “And sunscreens containing inorganic compounds like zinc oxide or titanium dioxide, that block UV rays, are being marketed more and more heavily as safe alternatives to the organic small-molecule compounds that absorb the rays,” Tanguay said. For example, oxybenzone has effectively been discontinued because of concerns that it harms coral reefs. What the public thinks about sunscreen safety has caused manufacturers, often based on limited data, to use lots of some ingredients while limiting others, she said. “Sunscreens are important consumer products that help to reduce UV exposures and thus skin cancer, but we do not know if the use of some sunscreen formulations may have unintended toxicity because of interactions between some ingredients and UV light,” said Tanguay, an OSU distinguished professor and an international expert in toxicology. The questions: How stable, safe, and effective are sunscreen ingredients in combination rather than as individual compounds – which is how they are considered for Food and Drug Administration approval – and what about the safety of any chemical products that result from reactions caused by exposure to sunlight? The research team, which included College of Agriculture Sciences faculty Robyn Tanguay and Lisa Truong and graduate fellow Claudia Santillan, sought to answer important but largely neglected questions regarding the massive global sunscreen market, predicted by market data firm Statista to be worth more than $24 billion by the end of the decade. ![]() The toxicity analysis involved zebrafish, which share a remarkable similarity to humans at the molecular, genetic and cellular levels, meaning many zebrafish studies are immediately relevant to people.įindings were published today in Photochemical & Photobiological Sciences. ![]() ![]() – Sunscreen that includes zinc oxide, a common ingredient, loses much of its effectiveness and becomes toxic after two hours of exposure to ultraviolet radiation, according to a collaboration that included Oregon State University scientists. ![]() ![]() ![]() We can see that if we’ve got less than a $100 we’re going to be stuck in a used Yugo. This rather simplified diagram illustrates the decisions involved in buying a car. For flow to progress through a guarded transition the guard must evaluate to true in the context of the decision point. The text shown in square brackets on transitions out of the decision points is called Guards. If Still Tired? is No then the flow transitions on to the Shut off Alarm and Get Out of Bed activities. The Get Out of Bed example uses a decision point “Still Tired?” If Still Tired? is Yes then the flow transitions to the Hit Snooze activity and then back to the Asleep state. There are two ways to draw logical branching in activity diagrams. There are nine transoms total in the example. In the Get Out of Bed example above, you can see that the Alarm Goes Off activity transitions to the Sleepy state. Transitions are used to indicate the process flow between elements in your diagram. The lines with open arrow heads are called Transitions. Activities are shaped like pills and have a description inside. In the previous example the activities were: Alarm Goes Off, Hit Snooze, Shut off Alarm and Get Out of Bed. This diagram is made up of the following notational elements: ActivitiesĪctivities are used to indicate actions which are preformed in your diagram. ![]() Here is an example Activity Diagram illustrating the Get Out of Bed use case: ![]() (In the ColdFusion world you really don’t need to worry about this difference.) The major difference is that activity diagrams allow for parallel processing of tasks. This is where Activity Diagrams come in.Īctivity Diagrams are very similar to standard flow charts. However, it doesn’t make any attempt to say anything about the steps involved. This Use Case diagram clearly states that Search Users will Search Content. For example, consider this Use Case diagram: Once you have gathered your Use Case diagrams you can continue on with the analysis phase by using Activity Diagrams.Īctivity Diagrams are used to illustrate the activities implicit in a use case. The Use Case diagram is a diagram used to gather requirements and help with analysis. In my last major entry on the UML I covered the Use Case diagram. ![]() |
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